…it’s the 66th anniversary of the most interesting bicycle ride EVER.
Albert Hofmann joined the pharmaceutical-chemical department of Sandoz Laboratories (now Novartis), located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides (an active principal of Mediterranean Squill). While researching lysergic acid derivatives, Hofmann first synthesized LSD-25 in 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic). It was set aside for five years, until April 16, 1943, when Hofmann decided to take another look at it. While re-synthesizing LSD, he accidentally absorbed a small quantity through his fingertips and serendipitously discovered its powerful effects before his bicycle ride home.