There’s a pretty good video floating around concerning what would happen if Superman punched you at full force, but it turns out it’s basically exactly the same riff that Randall Munroe did in his very first What If a few months ago when he answered the question “What would happen if you tried to hit a baseball pitched at 90% of the speed of light?”
Answer in both cases: rough equivalent of a GIANT-ASS NUCLEAR BOMB. But given Munroe’s profile at this point, it seems kinda unlikely that the Superman-fist guy hadn’t seen Munroe’s work, which makes his effort seem cheesy.